Pickering-class starships were a medium cruiser class in use in the 23rd century, used primarily for border patrols and scientific missions. The remaining ships of this class were scrapped or refit to the Constitution-class refit specifications. (Star Trek: The Cantabrian Expeditions)

The USS Cantabrian (NCC-607) was a Pickering-class starship before it was refit into a Constitution-class starship in 2271. (Star Trek: The Cantabrian Expeditions: "The Fire in Which We Burn")

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