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An isolation bay, or quarantine, was an area on a starship, starbase or other vessel or facility where medical officials quarantined a person or people with communicable diseases to prevent their spread among uninfected people.

In 2372, the USS Cantabrian's isolation bays, located on deck 4, were severely damaged in battle with the Myhr'an. (Star Trek: The Cantabrian Expeditions: "Catalyst, Part One") When Captain Noah Wrightson was infected with Caldean Acute Cardiopulmonary Syndrome (CACS) a few weeks later, he could not be transported back to the Cantabrian due to the isolation bays being damaged. (Star Trek: The Cantabrian Expeditions: "Isolation")

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