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The Gamma Quadrant was a Federation-centric name for the quarter of the Milky Way Galaxy encompassing the Dominion. (Star Trek: Deep Space Nine; Star Trek: Voyager; Star Trek: The Prospect Chronicles; Star Trek: The Cantabrian Expeditions)

The Bajoran wormhole led from the Alpha Quadrant into the Gamma Quadrant. (Star Trek: Deep Space Nine; Star Trek: The Prospect Chronicles)

In 2371, Rear Admiral Alexandra de Groot tasked the crew of the USS Prospect (NCC-60056) with making first contact with the Dominion. It ended in disaster. (Star Trek: The Prospect Chronicles: "Pure Massacre")

In 2372, the USS Prospect (NCC-60056-A) was assigned to retrieve the folded space drive prototype from the USS Rutherford (NX-76607), which was adrift in the Gamma Quadrant. The Prospect engaged in a cat-and-mouse game with Jem'Hadar forces in an attempt to keep the prototype out of Dominion hands. After finding evidence that Dr. Henrik Delaney and some Rutherford crew used the drive to escape the Dominion at the destroyed New Bajor colony, the Prospect scuttled the Rutherford and returned back to the Alpha Quadrant severely damaged from their battle with the Dominion. (Star Trek: The Prospect Chronicles: "Directive")

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Milky Way Galaxy quadrants
Alpha - Beta - Delta - Gamma
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