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Cardiac arrest was when an individual's heart suddenly stopped or slowed, affecting the blood flow within the circulatory system.

In 2372, Noah Wrightson, suffering from Caldean Acute Cardiopulmonary Syndrome, went into cardiac arrest but was revived by Daniel Radke by using twenty ccs of lectrazine. (Star Trek: The Cantabrian Expeditions: "Isolation")

In 2376, Doctor Marie Bourget tried to revive a Merchokan suffering a bi-cardiac arrest in both his hearts by using twenty ccs of hyperzine but was unsuccessful. (Star Trek: The Cantabrian Expeditions: "Howl")

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